The effect of selected corticosteroids for the treatment of osteoarthritis in horses. A literature review.
Item
- Title
- The effect of selected corticosteroids for the treatment of osteoarthritis in horses. A literature review.
- Author(s)
- Snook.A
- Abstract
- Background Corticosteroids have been used within the horse industry for Osteoarthritis by veterinary clinicians as a form of therapeutic treatment. Limited quantity of research has resulted in a small amount of literature validating the use of selected corticosteroids as a beneficial treatment of Osteoarthritis in horses. This review has been conducted to determine the most advantageous corticosteroid for the treatment of osteoarthritis in the horse based on the current literature available. Objectives This review aims to critically evaluate the results and quality of studies involving corticosteroids as treatment for osteoarthritis in horses, to see the effects from corticosteroid administration and underlining common weaknesses within the research and recommend improvements for future literature. Design A structured literature review. Methodology Three databases were searched using filters and keywords. Inclusion criteria: randomised controlled trials, peer-reviewed articles, full texts available, English language, published 1993-2018, title containing Betamethasone, Methylprednisolone Acetate or Triamcinolone Acetonide, control group, equine model. Exclusion criteria: articles which do not meet the inclusion criteria. Eight papers met the criteria for inclusion in this study. Data was extracted based on the study design, participant details, study aims (landmark assessed), limitations within the study and details of the outcome measures were analysed and compared when appropriate. Results Of the eight studies reviewed, the average study quality of selected trials report to a good standard with a mean CASP = 9.75, a mode = 10 and median = 10. Study practitioners worked within the equine veterinary field. No studies reported examiner experience impacting the influence of accuracy within the intervention phases. The studies were based on the osteochondral fragment model. One study reported corticosteroids do not significantly alter bone remodeling or fragility and another study showed significant differences between the treated and the control joints for collagen cleavage. Discussion The interpretation of study findings was restricted by heterogeneity in study methods, the test procedures and statistical reporting. The pathogenesis from intra articular corticosteroid administration needs to be investigated further including, potential deleterious and therapeutic effects on joint disease in the horse. Conclusion Further high-quality trials are necessary to establish the effects of Betamethasone, Methylprednisolone acetate and Triamcinolone Acetonide using larger sample sizes and double blinded trials.
- presented at
- European School of Osteopathy
- Date Accepted
- 2019
- Date Submitted
- 19.11.2019 18:31:10
- Type
- osteo_thesis
- Language
- English
- Submitted by:
- 62
- Pub-Identifier
- 16513
- Inst-Identifier
- 1229
- Keywords
- Corticosteroids, Betamethasone, Triamcinolone Acetonide, Methylprednisolone acetate, Osteoarthritis, outcome measures
- Recommended
- 0
- Item sets
- Thesis
Snook.A, “The effect of selected corticosteroids for the treatment of osteoarthritis in horses. A literature review.”, Osteopathic Research Web, accessed May 4, 2025, https://www.osteopathicresearch.org/s/orw/item/316